Table 1.
PP-19 disrupts stress-evoked but not basal-firing endocytosis.
| Evoked ICa | Rate of granule fusion | ΔCmAP−1 | Endocytic efficiency | |
|---|---|---|---|---|
| (pA) | (fF s−1) | (fF) | ||
| 15 Hz Control (n = 5) | 315 ± 91.1 | 38.55 ± 7.35 | 2.57 ± 0.49 | 0.81 ± 0.01 |
| 15 Hz PP-19 (n = 7) | 292 ± 55.5 | 33.75 ± 7.20 | 2.25 ± 0.48 | 0.33 ± 0.08 |
| 0.5 Hz Control (n = 17) | 572 ± 29.8 | 4.86 ± 1.63 | 9.72 ± 3.26 | 0.84 ± 0.18 |
| 0.5 Hz PP-19 (n = 8) | 590 ± 92.4 | 4.58 ± 0.56 | 9.15 ± 1.12 | 0.77 ± 0.26 |
AP, action potential. Evoked ICa is lower at 15 Hz than at 0.5 Hz presumably due to activity dependent inhibition of voltage-gated Ca2+ channels (Currie & Fox, 1996, 1997, 2000)