Figure 3.

Hepatic cytokine mRNA expression in fibrotic liver injury in SCID mice. Liver fibrosis was induced as in Fig. 1. Seven days after the 4th dose of CCl₄, animals were killed, total cellular RNA extracted, and competitive PCR using primers for IFN-γ, IL-4, TGF-β, and HPRT performed as described. A representative gel is shown in a. Scanned, quantitated, and normalized data are presented graphically in b. Circles represent C57BL/6 mice, and squares represent BALB/c animals. ∗, P < 0.05 for C57BL/6 compared with BALB/c mice (n = 4 for group).