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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Alzheimers Dement. 2008 Jan;4(Supplement 1):s153–s168. doi: 10.1016/j.jalz.2007.10.005

Figure 6.

Figure 6

Effects of oral supplementation with various doses of DHA on dendritic spine density in adult gerbil hippocampus. Animals were supplemented with 0, 50, 100 or 300 mg/kg of DHA daily for 4 weeks. (A) Apical dendrites of CA1 pyramidal neurons. (B) Animals supplemented with 100 or 300 mg/kg/day showed increased spine density: a 12 % increase after the 100 mg/kg/day dose (*P = .04) and an 18 % increase after the 300 mg/kg/day dose (**P < .001 vs. 0 mg/kg/day). n = 16 ∼ 20 neurons from 2 animals per group. (From Sakamoto T et al., Submitted for Publication)