Table 3.

Effects of giving UMP-supplemented diet (0.5%) and DHA (300 mg/kg) on phosphatide levels in different gerbil brain regions.

	Cortex	Striatum	Hippocampus	Brain Stem	Cerebellum
Total PL
Control diet + Vehicle	267	265	264	450	270
UMP diet + DHA	316**	339***	314**	521**	317**
PC
Control diet + Vehicle	94	100	102	114	98
UMP diet + DHA	122***	126*	117***	139***	111***
PE
Control diet + Vehicle	58	60	61	117	64
UMP diet + DHA	80**	85***	81***	156***	85***
PS
Control diet + Vehicle	24	24	24	30	24
UMP diet + DHA	30***	29*	28***	35***	29**
PI
Control diet + Vehicle	10.6	7.6	8.8	9.3	10.4
UMP diet + DHA	13.2**	11.9***	11***	11.8*	11.5*

Groups of gerbils were given a UMP-containing (0.5%) diet and, received by gavage, DHA (300 mg/kg; in a vehicle of 5% gum Arabic solution) or just the vehicle, for 28 days. On the 29th day various brain regions were harvested and assayed for phosphatides as described in the text. Data are presented as nmol/mg protein.

^*P<0.05

^**P<0.01

^***P<0.001 compared to Control diet + Vehicle group using Student's t test. (From Cansev M and Wurtman RJ, In Press)