Table 1.
Liver Selenium and Vitamin E Status of Micea
| experimental diets | ||||
|---|---|---|---|---|
| micronutrient biomarker | mouse genotype | control | selenium-deficient | vitamin E-deficient |
| Gpx activityb
(U/mg protein) |
Nrf2+/+ | 370 ± 32 (5) | n.d. (5) | 330 ± 50 (5) |
| Nrf2−/− | 310 ± 21 (5) | n.d. (4) | 270 ± 39 (5) | |
| vitamin Ec
(nmol/g liver) |
Nrf2+/+ | 66 ± 25 (4) | 82 ± 20 (4) | n.d. (4) |
| Nrf2−/− | 91 ± 28 (4) | 73 ± 43 (4) | n.d. (4) | |
a
Values are means ± S.D. (n). n.d. indicates not detectable. Values of 0 U/mg protein and 10 nmol/g liver were used for detection limits of Gpx activity and vitamin E concentration, respectively, in statistical calculations.
b
Both selenium-deficient values were different (p<0.05) from all other values. No other values were different from each other.
c
Vitamin E determinations were made on livers from the 16-week experiment because there was insufficient liver available from the 22-week experiment. Both vitamin E-deficient values were different (p<0.05) from all other values. No other values were different from each other.