Table 3. Summary of stationary GC-content (GC*) and base-specific substitution rates in the human lineage and their pairwise correlations with the current GC-content (GC), crossover rate (CO) and the distance to telomeres (LDT).

Variables		Average	Pairwise correlations
			Current GC			CO			LDT
			Sign	R2	p	Sign	R2	p	Sign	R2	p
Stationary GC-content (GC*)		0.37	+	0.25	<10−10	+	0.36	<10−10	−	0.35	<10−10
Substitution rates:
W→S	A:T→G:C	0.0031		0.000	NS	+	0.20	<10−10	−	0.22	<10−10
	A:T→C:G	0.0009	+	0.004	0.002	+	0.17	<10−10	−	0.21	<10−10
S→W	C:G→T:A (CpG)	0.0540	−	0.42	<10−10	−	0.04	<10−10	+	0.04	<10−10
	C:G→T:A (non-CpG)	0.0039	−	0.13	<10−10		0.000	NS		0.000	NS
	C:G→A:T	0.0013	−	0.26	<10−10	−	0.01	6 10−9	+	0.005	3 10−4
W→W	A:T→T:A	0.0007	−	0.10	<10−10	+	0.004	0.003	−	0.01	2 10−5
S→S	C:G→G:C	0.0013	−	0.005	8 10−4	+	0.06	<10−10	−	0.10	<10−10

Data: autosomes, 1 Mb windows. Crossover rates from HAPMAP. NS: non-significant. R²: Pearson's correlation R². The sign of the correlation is indicated (when significantly different from zero).