Table 1.

Effect of inhibitors on JSRV induced cell transformation of 208F cells

Pathway	Inhibitor name	Inhibitor concentration (uM)	Inhibition of transformationa (%)	Reversion of transformed phenotype
Janus protein tyrosine kinase	JAK inhibitor I	0.001	n.a.b	No
		0.005	n.a.	No
		0.01	n.a.	No
		0.015	n.a.	No
		0.05	n.a.	No
		0.15	0	No
VEGFR	VEGF receptor 2 kinase inhibitor III	1	0	No
		20	n.a.	Txc
SRC (family)	PP2	5	41	No
		10	73.4	No
	PP1	0.0015		No
		0.015	0	No
	Genistein	25	11.9	No
	Inhibitor I	0.044	n.a.	No
		0.088	n.a.	No
		0.44	n.a.	No
		0.88	0	No
	Inhibitor II	1.2	0	No
		12	TX	Tx
	Emodin	0.018	n.a.	No
		18.5	0	No
		185	n.a.	Tx
	SU 6656	0.28	n.a.	No
		1	22	n.a.
		2.8	65.9**	Yes
	Lavendustin C	2	4	No
	Damnacanthal	0.017	n.a.	No
		0.17	0	No
Platelet derived growth factor receptor (PDGF)	Inhibitor I	0.2	n.a.	No
		2	n.a.	No
	Inhibitor II	1.1	n.a.	No
		11	57.5	No
	Inhibitor III	0.05	n.a.	No
		0.08	20	No
		0.5	n.a.	No
		0.8	0	No
	AG 1296	1	n.a.	No
		10	n.a.	No
	AG 2043	1	n.a.	No
		10	29.2	No
EGFR	PD 153035	0.000025	n.a.	No
		0.00025	0	No
	AG 1478	0.003	n.a.	No
		0.03	0	No
HSP 90	Herbimycin A	0.2	96	n.a.
		0.4	100	Yes
	Geldanamycin	0.0017	0	n.a.
		0.0075	74	n.a.
		0.0187	90	n.a.
		0.0375	97.9	Yes
		0.075	Tx	Yes
		0.75	Tx	Yes
	Radicicol	0.27	n.a.	Yes
		2.7	55.7	Yes
	17-DMAG	0.5	88.8	Yes

^aInhibition of transformation was calculated by comparing the number of foci obtained by the JSRV Env in the presence of each inhibitor or in the presence of DMSO alone (taken as 100%). Values shown are the average of at least two experiments.

^bNot analysed

^cA toxic effect was evident at these concentrations