TABLE I.
Effects of Amphiphiles on Bilayer Stiffness and VDSC Function
| gA
|
VDSC
|
|||
|---|---|---|---|---|
| Amphiphile | Bilayer stiffness | Activation | Inactivation | |
| Positive c0 | LPC | ↓(a) | ↓(b) | ↑(b) |
| Triton X-100 | ↓(c) | 0(c) | ↑(c) | |
| Reduced Triton X-100 | ↓(c) | 0(c) | ↑(c) | |
| Genapol X-100 | ↓(c) | 0(c) | ↑(c) | |
| β-Octyl Glucoside | ↓(c) | 0(c) | ↑(c) | |
| Pentobarbital | ↓(d) | 0(e) | ↑(e) | |
| Valproate | ↓(d) | 0(f) | ↑(f) | |
| Diazepam | ↓(d) | 0(g) | ↑(g,h) | |
| Capsazepine | ↓(i) | 0(i) | ↑(i) | |
| Genistein | ↓(j) | 0↓(k,r) | ↑(k,r) | |
| Negative c0 | Capsaicin | ↓(i) | 0↓(i) | ↑(i) |
| Docosahexaenoic acid | ↓(n) | 0(o) | ↑(o) | |
| Arachidonic acid | ↓(q,l) | 0(s) | ↑(s) | |
| Chlorpromazine | ↓(d) | 0(m,g) | ↑(m,g) | |
| Oleic acid | 0(n) | 0(o) | 0(o) | |
| Cholesterol | ↑(c,p) | ↓(c) | ↓(c) | |
(a) Lundbæk and Andersen, 1994, (b) Shander et al., 1996, (c) Lundbæk et al., 2004, (d) Sun, Y., V. Jogini, and O.S. Andersen. 2002. Biophys. J. 82:550a, (e) Rehberg et al., 1995, (f) Schauf, 1987, (g) Wakamori et al., 1989, (h) Backus et al., 1991, (i) Lundbæk et al., 2005, (j) Hwang et al., 2003, (k) Wang et al., 2003, (l) Bruno et al., 2006, (m) Ogata and Narahashi, 1989, (n)Bruno et al., 2007, (o)Vreugdenhil et al., 1996, (p) Lundbæk et al., 1996, (q) Bruno et al., 2005, (r) Paillart et al., 1997, (s) Lee et al., 2002.