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. Author manuscript; available in PMC: 2009 Apr 2.
Published in final edited form as: Mutat Res. 2008 Jan 16;640(1-2):174–179. doi: 10.1016/j.mrfmmm.2008.01.001

Fig. 2. Hypoxia induces altered post-translational modifications of total histone populations.

Fig. 2

Modifications of histones, associated with transcriptional activation and repression, were determined by immunoblotting of protein extracts of Hepa 1–6 cells grown under normoxia or 0.2% oxygen for 48 hrs (representative blots, Supplemental Fig. 1). Quantified values, generated by NIH image, were normalized to H3-C-terminus, and fold change (H/N) is graphed. The average was generated from quantified values, obtained by NIH image, from three independent immunoblots of three independently obtained normoxic and hypoxic extracts. Error bars denote the SEM.