TABLE 3.
Scedosporium infection: clinical response and underlying conditiond
| Underlying disease, no. (%) | Range of therapy in days (median) | No. with successful outcome/total no. (%) | Known survival range in days (median) | No. of patients alive/total no. (no. of deaths due to IFI) |
|---|---|---|---|---|
| HSCT, 10 (9) | 1-799 (73) | 4/10 (40) | 1-799 (94) | 4/10 (4) |
| Hematological malignancy, 22 (21) | 1-540 (30) | 10/22 (45) | 2-720 (34) | 7/22 (11) |
| SOT, 24 (22) | 13-487 (139) | 15/24 (63) | 13-720 (140) | 15/24 (7) |
| Other hematological conditions,a 5 (5) | 32-691 (138) | 3/5 (60) | 32-816 (138) | 4/5 (1) |
| Other malignancy,b 7 (7) | 8-150 (90) | 3/7 (43) | 9-1,440 (108) | 3/7 (2) |
| Other,c 29 (27) | 9-802 (179) | 21/29 (72) | 9->2,000 (221) | 26/29 (3) |
| High-dose steroids, 10 (9) | 3-495 (96) | 5/10 (50) | 3-720 (96) | 5/10 (4) |
| Total, 107 | 1-802 (103) | 61/107 (57) | 1->2,000 (133) | 64/107 (32) |
a
Other hematological conditions: chronic granulomatous disease (four) and angioimmunoblastic lymphadenopathy (one).
b
Other malignancy: non-Hodgkin's lymphoma (three), laryngeal carcinoma (one), prostate cancer (one), Waldenstrom's macroglobulinemia (one), and choroid plexus tumor (one).
c
Other: trauma/postsurgery (16), diabetes (five), none (three), near-drowning (two), idiopathic pulmonary fibrosis (one), vasculitis (one), and chronic immune deficiency (one).
d
Abbreviations: HSCT, hematopoietic stem cell transplantation; IFI, invasive fungal infection; SOT, solid organ transplant.