TABLE 5.
Anti-HIV activity of NRTIs on HIV-1 strains containing the M184V substitutiona
| NL4-3 virus | ETV
|
LVD
|
AZT
|
EFV
|
||||
|---|---|---|---|---|---|---|---|---|
| EC50 (μM) | FC | EC50 (μM) | FC | EC50 (μM) | FC | EC50 (μM) | FC | |
| Wild type | 0.056 | NA | 0.040 | NA | 0.010 | NA | 0.0002 | NA |
| M184V mutant | >10 | >178 | >10 | >250 | 0.005 | 0.5 | 0.0002 | 1.0 |
| Monogram wild type | 30.6 | NA | ND | ND | ND | ND | ND | ND |
| Monogram M184V mutant | >100 | >3.2 | ND | ND | ND | ND | ND | ND |
a
Values shown are the averages of two experiments performed in duplicate. FC, fold change (mutant versus wild type). NA, not applicable; ND, not done.