TABLE 2.
Frequency of resistant-colony formation after single or combination selection
| Selection (n)a | Mean no. of colonies ± SDb | Frequency (%)c |
|---|---|---|
| 10× HCV-796 (10) | 60 ± 15 | 0.060 |
| 10× HCV-796/1× R1479 (6) | 23 ± 9 | 0.023 |
| 10× HCV-796/1× PSI-6130 (4) | 6 ± 8 | 0.006 |
| 15× HCV-796 (10) | 36 ± 12 | 0.036 |
| 15× HCV-796/1× R1479 (6) | 12 ± 8 | 0.012 |
| 15× HCV-796/1× PSI-6130 (4) | 2 ± 3 | 0.002 |
| 15× VX-950 (7) | 93 ± 16 | 0.093 |
| 15× VX-950/1× R1479 (4) | 44 ± 30 | 0.044 |
| 15× VX-950/1× PSI-6130 (4) | 4 ± 4 | 0.004 |
a
Replicon cells were selected with 1, 10, or 15 times the EC50 of the indicated compounds.
b
Replicon cells were stained with crystal violet after undergoing selection for 3 weeks, and the number of colonies remaining were counted.
c
Frequency determined as number of colonies/initial number of cells × 100.