FIG. 1.

Effective treatment window for i.p. administration of pyocin. Female CD-1 mice were infected with LD₉₀ inocula of strain 13s P. aeruginosa. A cohort of 10 infected animals was not treated, to verify that the inocula were at the LD₉₀ value. At each of the indicated times after infection, 10 animals were treated once i.p. with 3 × 10¹¹ pyocins in 0.1 ml. If and when animals first appeared moribund, they were euthanized, and survivors were counted at 24 (broken line) and 48 (solid line) hours postinfection.