FIG. 3.

Evaluation of transmission-blocking activity by passive immunization. Mice were infected with TrPfs25Pb and used to assess transmission to mosquitoes before and after administration of rhesus preimmune or anti-Pfs25 immune sera. Mosquito midguts were examined 10 days postfeeding. Data points represent the number of oocysts found in individual mosquitoes that fed on three mice/group. Numbers on top of each set of data points indicate the percent mosquitoes infected (total number of mosquitoes dissected), and those next to horizontal lines indicate the mean number of oocysts. The reduction in the number of oocysts/mosquito by immune sera was significant (P < 0.001; Wilcoxon test).