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Properties of the selected cross-linking agents
| Linking agent | Spacer arm (Å)a | Reactive group | Functional groupb | Cleaving reagent(s) |
|---|---|---|---|---|
| Sulfo-DST | 6.4 | NHS-ester | Amine | None |
| BS3 | 11.4 | NHS-ester | Amine | None |
| DTSSP | 12.0 | NHS-ester | Amine | Thiols |
| Sulfo-EGS | 16.1 | NHS-ester | Amine | Hydroxylamine |
| Sulfo-SAND | 18.5 | NHS-ester/aryl azide | Amine, nonselective | Thiols |
Length of the spacer arm in angstroms.
Target of reactive group.
