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. 2008 Mar 3;76(5):2002–2007. doi: 10.1128/IAI.01588-07

FIG. 1.

FIG. 1.

Mycolactone injection into mouse footpad evoked swelling, hyperesthesia, nerve damage, and systemic pathology. Various amounts (30, 100, and 200 μg) of mycolactone A/B were injected into the left footpads of BALB/c mice. (A) Footpad swelling on day 7 after the injection of 100 μg (arrow). (B) Footpad thickness on day 7. Dose-dependent swelling was significant. (C) Sensory test showing hyperesthesia on day 7 (P = 0.02). (D) Nerve bundles showed a loss of Schwann cell nuclei and intraneural hemorrhage (H&E; magnification, ×168). (E) Lung without mycolactone injection (H&E, magnification, ×168). (F) Intra-alveolar hemorrhage in the lungs of mice injected with 200 μg of mycolactone into the footpad (H&E, magnification, ×168).