FIG. 1.
IL-12 protein concentration in lung homogenate and BAL fluid of wild-type mice infected with Pneumocystis carinii. Mice were infected with 2 × 105 Pneumocystis carinii organisms IT on day 0 and sacrificed immediately or on days 7, 14, 21, or 28 postinfection. IL-12 p40 and p70 cytokine levels in lung homogenate (A and C) or BAL fluid (B) were determined by multiplex cytokine assay (Bio-Plex; Bio-Rad, Hercules, CA). IL-12 p70 was not detectable in the BAL fluid. Data are reported as mean ± SEM, n = 3 to 10. * indicates P < 0.01 compared to day 0.