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. 2008 Mar 10;76(5):2130–2137. doi: 10.1128/IAI.00065-08

FIG. 4.

FIG. 4.

Gene transfer of rmIL-12 using an adenoviral vector. (A) Wild-type control mice received various doses of IL-12 in the adenoviral vector by IT inoculation, and IL-12 was assayed in lavage fluid after 3 days. (B) IL-12 concentrations in lavage fluid in control (CD4+) and CD4-depleted (CD4−) mice 1 week after administration of 2 × 108 PFU of AdIL-12 or AdLuc (Luc). (C) Control and CD4-depleted BALB/c mice were challenged with 2 × 105 P. carinii (PC) organisms. Twelve days after challenge, mice were administered either 2 × 108 PFU AdIL-12 or AdLuc by IT inoculation. Mice were sacrificed at 4 weeks, and lung homogenate was assayed via real-time PCR for P. carinii rRNA. Data are reported as mean ± SD, n = 5 or 6. * indicates P < 0.05 compared to AdLuc.