TABLE 1.
Passive immunization of mice with serum from animals that had been immunized with Y. pestis KIM D27
| Challenge straina | No. of animals with 14-day survival/no. of animals challengedb with:
|
|||
|---|---|---|---|---|
| Naïve mouse serum at dilution of 1:1 | Anti-KIM D27 serum at dilution of:
|
|||
| 1:1 | 1:2 | 1:4 | ||
| Y. pestis CO92, wild type | 0/5 | 4/5 | 5/5 | 1/5 |
| Y. pestis CO92 ΔF1 | 0/5 | 1/5 | 0/5 | 0/5 |
a
Passively immunized BALB/c mice were challenged by subcutaneous inoculation with 20 CFU of Y. pestis strains.
b
Passive immunization occurred 1 h prior to challenge by intraperitoneal injection of 250 μl of serum. Serum was diluted in PBS.