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. 2008 Mar 12;82(10):5031–5042. doi: 10.1128/JVI.02069-07

FIG. 3.

FIG. 3.

Longitudinal analysis of SIV p27 production in MDMs and nonadherent PBMCs from six pigtailed macaques infected with SIVDeltaB670. Based on necropsy histological findings, macaques were retrospectively classified for presence of SIVE. (a) At various times during the course of infection, p27 production of MDMs (adherent PBMCs) cultured ex vivo for 14 days showed that the four macaques that developed SIVE (solid black symbols) produced more p27 in culture than the two macaques without encephalitis (open gray symbols). MDMs from each macaque that developed SIVE had peak ex vivo virus production at different times postinfection, mostly within the first 8 weeks postinfection. (b) Peak p27 production from MDMs cultured ex vivo. (c) Longitudinal p27 production levels of nonadherent PBMCs cultured ex vivo for 14 days were increased at various times postinfection from the four macaques that developed SIVE (solid black symbols) compared to the levels in two macaques without encephalitis (open gray symbols). (d) Peak p27 production from nonadherent PBMCs cultured ex vivo.