FIG. 7.

Breadth of responses elicited by the heterologous rAd26/rAd5 regimen in rhesus monkeys. Breadth of Gag-specific cellular immune responses is shown for the rhesus monkeys (n = 3) that received the rAd26-Gag prime, rAd5-Gag boost regimen described for Fig. 6. IFN-γ ELISPOT responses to each of the 125 individual SIV Gag peptides were assessed 4 weeks following the rAd26-Gag priming immunization (A) and 4 weeks following the rAd5-Gag boost immunization (B). Data presentation uses a logarithmic y axis to emphasize the breadth of epitope-specific cellular immune responses. The horizontal bars indicate an arbitrary definition of 30 SFC/10⁶ PBMC positive responses.