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. Author manuscript; available in PMC: 2008 Apr 28.
Published in final edited form as: Mol Pharmacol. 2006 Jul 28;70(5):1494–1502. doi: 10.1124/mol.106.026625

Fig. 1.

Fig. 1

Effects of UCL2077 on the sAHP recorded from dissociated hippocampal neurons. A, The chemical structure of UCL2077. B, the time course of block of the sIAHP by 3 μM UCL2077 in cultured hippocampal neurons. At −55 mV, there is an outward holding current (in this case, 120 pA), which UCL2077 partially suppressed. The effect on the holding current is variable (between 5 and 40%, as noted in the text). Action potentials have been removed for clarity. The mIAHP was unaffected in the presence of UCL2077, and this is more clearly shown on an enhanced time scale in C. In addition, sometimes the sIAHP increased with time; in this particular cell, that seems to be the case in that there is an over-recovery upon washout of UCL2077. C, effects of UCL2077 shown on an enhanced time scale. The traces shown correspond to (i), (ii), and (iii) in B. D, concentration-inhibition curve for UCL2077. The numbers of observations for each concentration are shown above the symbol.