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. Author manuscript; available in PMC: 2009 Mar 1.
Published in final edited form as: J Mol Cell Cardiol. 2008 Jan 17;44(3):502–509. doi: 10.1016/j.yjmcc.2008.01.002

Figure 1.

Figure 1

RT-PCR analysis of hERG mRNA isolated from lymphocytes. A: mRNA was isolated from a normal subject (NS) and the proband of family 2. RT- PCR was performed using primers in exon 8 and exon 10 as indicated by arrows. Control lanes: no reverse transcriptase in RT reaction. Similar results were obtained from another mutation carrier of this family and two independent experiments were performed for each patient. B: Sequence analysis of the 362 bp product from a normal subject (top panel) and the 416 bp product from the proband (bottom panel). Arrow head indicates the 2398+1G>C mutation. C: Schematic presentation of normal and cryptic splicing.