GHR distribution. After treatment with insulin or
IGF-I, total (□), surface (░⃞), and intracellular
GH binding (▪) were determined as described in
Materials and Methods. The control values for total,
surface, and intracellular GH binding were 2,459 ± 209 cpm/mg,
112 ± 20 cpm/106 cells, and 1,723 ± 103
cpm/mg, respectively. Vs. control, ∗, P <
0.05; ‡, P < 0.005; and †,
P = 0.0001.