Figure 4.

GHR translocation. GHR translocation was measured as the recovery of GH binding on the cell surface after removal of the surface GHR by trypsinization. The trypsinized cells were allowed to recover at 22°C for the time periods indicated, followed by GH binding assay. Results from a representative experiment were shown, and similar findings were obtained in four other experiments. □, Control; •, insulin; ○, IGF-I. Vs. 0 hr, ∗, P < 0.05.