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Dissemination in IRF-1−/− mice. Mice were infected with 1 × 107 CFU/mouse bioluminescent B. melitensis strain GR023 or an isogenic deletion mutant, ARL01 (GR023ΔvjbR) or ARL02 (GR023ΔblxR), and imaged every 2 days beginning on day 1 (immediately postinfection). The numbers indicate days postinfection. Mice infected with GR023 and GR023ΔblxR died 7 days postinfection.
