Skip to main content
. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: Bone. 2008 Jan 12;42(4):606–615. doi: 10.1016/j.bone.2007.12.224

Figure 1.

Figure 1

A simplified diagram of the potential effects of tissue deformation on osteocytes. With the application of mechanical loading to the bone, bone matrix is deformed. Deformation of the bone matrix surrounding osteocytes could lead to the perturbation of bone fluid leading to shear stress. Alternatively or in combination with, tissue deformation could lead to perturbation of the cell membrane (whether the cell body or the dendritic processes) through tethering elements thought to be present in the glycocalyx. It is most likely that both contribute to mechanosensation and mechanotransduction.