Figure 4.
Carboxy terminal sequences with protein translations, secondary structure predictions, and phosphorylation sites for Alpha-2, SpV-1 (protein isoform 1) and SpV-2 (protein isoform 2). Garnier-Robbins secondary structure predications Alpha helix (A), Beta Sheet (B), Coil (C), and Turn (T) are shown below the protein sequence. Predicted phosphorylation sites are underlined and highlighted in yellow. Catalytic triad residues Asp193 and His196 in Alpha-2 are highlighted in red. Common sequence encoded by exon 5 is in green, exon 6 cDNA sequence (Alpha-2) is in black, AE-C sequence is in orange, and AE-B cDNA sequence is in blue. Amino acids 1–137 are identical for all three proteins; residues 1–123 are not shown. Stop codons are marked with *.