Figure 4.

An alignment of a portion of the COOH-terminal lobe of a cytoplasmic tyrosine kinase (c-src) and representative receptor tyrosine kinases (all other samples) (49, 53). The locations and relative activities of seven of the Met mutations analyzed are shown above affected residues. Conserved amino acids are shown in black. Residues, which, when mutated, activate the Kit and Ret receptors, are shown in broken black boxes. See text for additional details. See note added in proof.