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. Author manuscript; available in PMC: 2009 Apr 8.
Published in final edited form as: Eur J Pharmacol. 2008 Jan 19;583(2-3):194–203. doi: 10.1016/j.ejphar.2007.11.062

Figure 3.

Figure 3

Schematic depicting potential consequences of CRF morphological effects on locus coeruleus dendrites. In contrast to autonomically-related CRF afferents to the locus coeruleus that terminate in the nuclear core, limbic sources of CRF terminate outside of the core in the peri-coerulear region where locus coeruleus dendrites extend. By promoting the extension of locus coeruleus dendrites into this region, CRF potentially increases the probability that these dendrites will synapse with limbic afferents that convey affective information and enhance the influence of these afferents on locus coeruleus activity. Through this mechanism, CRF can determine the structural basis for emotional arousal.