Table 5.
Impact of bosentan therapy in chronic thromboembolic pulmonary hypertension (CTEPH)
| Study | Indication | n | Treatment duration | Parameter showing improvement |
|---|---|---|---|---|
| Bonderman et al 2005 | Inoperable CTEPH | 16 | 6 months | NYHA functional class 6-MWDa |
| Hoeper, Kramm et al 2005 | Inoperable CTEPH | 19 | 3 months | Hemodynamics 6-MWD |
| Hughes | Inoperable CTEPH/ Persistent PH after surgery | 20 | >3 months | Hemodynamics 6-MWD |
| Hughes | Inoperable CTEPH/ Persistent PH after surgery | 47 | 1 year | WHO functional class Hemodynamics 6-MWD |
a
Abbreviation: 6-MWD, six minute walk test distance.