Table 6.
Recommended dosing regimens for bosentan in adults and children
| Starting dose (1st 4-weeks) |
Maintenance dose (Week 5 onwards) |
|
|---|---|---|
| Adults (>12 years of age) | ||
| Bodyweight > 40 kg | 62.5 mg twice daily | 125 mg twice daily |
| Bodyweight < 40 kg | 62.5 mg twice daily | 62.5 mg twice daily |
| Children (<12 years of age) | ||
| Bodyweight <10 kg | 15.6 mg daily | 15.6 mg twice daily |
| Bodyweight 10–20 kg | 31.25 mg daily | 31.25 mg twice daily |
| Bodyweight 20–40 kg | 31.25 mg twice daily | 62.5 mg twice daily |
| Bodyweight >40 kg | 62.5 mg twice daily | 125 mg twice daily |