Table 1.
Characteristics of 459 patients with hypertension, who were not at goal blood pressure (either or both of systolic or diastolic BP) at baseline, stratified by albuminuria status
| Characteristic | Normal (n = 261) |
Albuminuria Status* | p-value | |
|---|---|---|---|---|
| Micro-albuminuria (n = 126) |
Micro-albuminuria (n = 72) |
|||
| Mean age (SD) | 55.4 (12.9) | 57.4 (13.1) | 59.7 (13.8) | 0.046 |
| African American race, n (%) | 225 (86.2) | 113 (89.7) | 70 (97.2) | 0.030 |
| Male gender, n (%) | 72 (27.6) | 43 (34.1) | 29 (40.3) | 0.09 |
| BMI > 30 kg/m2, n (%) | 140 (55.8) | 79 (63.7) | 43 (60.6) | 0.32 |
| Diabetes, n (%) | 54 (20.7) | 58 (46.0) | 45 (62.5) | <0.001 |
| Mean baseline therapeutic intensity score (SD) | 1.8 (1.1) | 2.3 (1.3) | 2.3 (1.0) | <0.0001 |
| Mean baseline number of antihypertensive medications (SD) | 3.0 (1.4) | 3.5 (1.3) | 3.8 (1.1) | <0.0001 |
| Mean baseline SBP, mmHg (SD) | 164.9 (22.8) | 178.0 (28.5) | 181.0 (27.7) | <0.001 |
| Mean difference from SBP goal (SD) | 31.4 (22.3) | 45.7 (27.6) | 50.8 (27.8) | <0.001 |
| Mean baseline DBP, mmHg (SD) | 96.9 (15.0) | 100.7 (17.3) | 96.7 (20.9) | 0.053 |
| Mean difference from DBP goal (SD) | 14.4 (11.8) | 20.2 (14.0) | 24.1 (17.5) | <0.001 |
| Mean eGFR [ml/min/1.73 m2] (SD) | 80.9 (23.6) | 72.7 (24.4) | 54.1 (20.3) | <0.001 |
| eGFR < 60 ml/min/1.73 m2, n (%) | 46 (17.6) | 38 (30.2) | 41 (56.9) | <0.001 |
| Mean post-baseline SBP response (SD) | 26.6 (21.4) | 27.8 (28.2) | 24.7 (26.7) | 0.80 |
| Mean post-baseline DBP response (SD) | 14.3 (11.5) | 15.0 (13.1) | 15.8 (13.7) | 0.50 |
| Attained S/DBP Goal, n (%) | 168 (64.4) | 59 (46.8) | 25 (34.7) | <0.001 |
*
Note: Normal = <30 mg/g creatinine; micro-albuminuria = 30–300 mg/g creatinine; macro-albuminuria = >300 mg/g creatinine.
Abbreviations: BMI, body mass index; eGFR, estimated glomerular filtration rate; SBP, systolic blood pressure; DBP, diastolic blood pressure; Goal BP, comorbidity-specific goal blood pressure as defined by JNC-VII guidelines.