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. Author manuscript; available in PMC: 2009 Mar 15.
Published in final edited form as: Virology. 2007 Dec 3;372(2):291–299. doi: 10.1016/j.virol.2007.11.002

Figure 2.

Figure 2

Non-integrated mutant virus SIVsmD116N does not replicate in host cells. Reverse transcriptase assay was carried out to evaluate infectivity of the WT and SIVsmD116N mutant in CEM×174 cells (2A), macaque PBMC (2B) and macaque MDM (2C). The WT virus replicated well in CEM×174 cells, macaque PBMCs as well as in MDM. In contrast, no RT activity was observed in cell-free media following infection with the integrase mutant SIVsmD116N in any of these cell types.