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. 1997 Sep 30;94(20):10844–10849. doi: 10.1073/pnas.94.20.10844

Figure 6.

Figure 6

Antibody responses of wild-type mice (+/+) and CD81-deficient (−/−) mice. (A) Response to the TD antigen TNP-KLH. Mice were immunized i.v. with 100 μg of TNP-KLH conjugate 1:25) in PBS at day 0 and boosted at day 21. (B) response to type I TI antigen TNP-LPS. Mice were immunized i.p. with 10 μg TNP-LPS in PBS at day 0. (C) Response to the type II TI antigen TNP-Ficoll. Mice were immunized i.p. with 10 μg TNP-Ficoll in PBS at day 0. Sera were diluted 1/1,000 and levels of antigen-specific antibody responses of the indicated isotypes were analyzed by TNP-specific ELISA. Mean values ± 2 SD obtained for the four mice per group are shown. ∗, P < 0.005; ∗∗, P < 0.01.