Table 1.

Body weights (g) and serum pituitary hormone levels

	Wild type	Heterozygous	Homozygous
Body weight (4 weeks, male)	20.8  ± 0.75 (7)	20.2  ± 0.48 (8)	14.5  ± 0.47 (10)***
Body weight (8 weeks, male)	29.0  ± 0.4 (10)	29.4  ± 0.5 (19)	28.1  ± 0.21 (12) NS
TSH (ng/ml)	76.0  ± 3.5 (13)	83.7  ± 4.4 (10)	139.1  ± 7.3 (13)**
PRL (ng/ml)	12.7  ± 1.8 (7)	13.5  ± 3.2 (8)	10.7  ± 2.2 (10) NS
GH (ng/ml)	41.3  ± 3.2 (9)	47.4  ± 4.5 (7)	45.2  ± 9.7 (11) NS
T4 (μg/dl)	5.94  ± 0.28 (13)	5.54  ± 0.35 (8)	3.30  ± 0.27 (13)***

Serum TSH, PRL, GH, and T4 levels were determined in 8-week-old male mice. Data represent means ± SEM (numbers of mice in parentheses). Significance of differences between wild-type and mutant animals is indicated: ∗∗∗, P < 0.001; ∗∗, P < 0.01; NS, not significant.