Table 3.

P53 mutations identified from RA synovial tissues

Patient	Predicted amino acid at mutation site	Nucleotide sequence change	Base change
RA429	R333H	CGT > CAT	G > A
	N239S	AAC > AGC	A > G
	L369fs	G deletion, base 1028	G deletion
RA430	V203V (conserved)	GTG > GTA	G > A
	I232M	ATC > ATG	C > G
RA435	L188L (conserved)	CTG > CTA	G > A
RA436	E224fs	G deletion, base 791	G deletion
RA445	Two mutations in a  single clone: R174G; G199G	AGG > GGG and GGA > GGG	A > G and A > G
RA453	Two mutations in a  single clone: K139R; H193Y	AAG > AGG and CAT > TAT	A > G and C >T
RA457	L257E	CTG > CAG	T > A

All of the subclones that were sequenced from the second-round mismatch analyses from Table 2 are presented. fs, frame shift.