S |
proportion susceptible to both strains |
Ii
|
proportion in primary infection with strain i={1,2} |
Ri
|
proportion immune to strain i only |
Ji
|
proportion in secondary infection with strain i={1,2} |
R |
proportion immune to both strains |
V |
proportion vaccinated and still immune to strain 1 |
IV2
|
proportion vaccinated and infected by strain 2 |
β |
rate of transmission |
γ |
rate of recovery |
μ |
birth and death rate |
p |
vaccine coverage (proportion of newborns vaccinated) |
σ |
rate of loss of natural immunity |
σV
|
rate of loss of vaccine immunity |
θ |
cross-protection conferred by primary infection (reduction in susceptibility) |
ν |
cross-protection conferred by primary infection (reduction in infectious period) |
τ |
cross-protection conferred by vaccination (reduction in susceptibility) |
η |
cross-protection conferred by vaccination (reduction in infectious period) |
R0
|
basic reproductive ratio of the pathogen: R0=β/(γ+μ) |