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. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: Dev Biol. 2008 Jan 8;316(1):50–61. doi: 10.1016/j.ydbio.2007.12.042

Figure 7. Model for mutual regulatory relationship between the Rb/E2F and MAP kinase pathways in the C.elegans germ line.

Figure 7

In this model, depending on the place and time in germ cell development, MAP kinase either controls DPL-1 function or vice versa. DPL-1 can exist in a regulatory complex with EFL-1 to promote lip-1 expression in mid-pachytene. XXX represents an unknown external signal that results in spatially-restricted activation of MAP kinase, possibly through blocking LIP-1 function. Once cells move beyond reach of the signal, LIP-1 inactivates MPK-1 in the proximal gonad. DPL-1 might also exist in a separate complex with LIN-35 to promote chromosome condensation. This complex is inhibited by MAP kinase in late pachytene through phosphorylation of DPL-1 to promote normal chromosome morphology.