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Effect of silymarin at doses of 100 mg/kg, 250 mg/kg and 500 mg/kg on (A) heart rate, (B) Mean arterial blood pressure and (C) pressure-rate product in rats during occlusion of the left anterior descending coronary artery for 30 min and subsequent reperfusion for 4 h. Values are mean ± SD of five animals. AR After reperfusion; BO Before occlusion; BOTC Before opening thoracic cavity; MOP Middle of occlusion period
