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. 2008 Mar 18;98(7):1226–1233. doi: 10.1038/sj.bjc.6604287

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Copyright © 2008 Cancer Research UK

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.

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The effects of preincubation with CPEC on the effects of dFdC with respect to cell proliferation (A and B), loss of clonogenic capacity after correction for the cytotoxicity of CPEC alone ((C) Panc-1: 0.71±0.12; Miapaca-2: 1.00±0.06; SWp: 1.07±0.08; SWg: 0.85±0.26) and induction of apoptosis (D) in human pancreatic carcinoma (Panc-1, Miapaca-2 and BxPC-3) and NSCLC cells (SWp and its dFdC-resistant variant SWg). Representative examples (A and D) or means with standard errors of at least three separate experiments (B and C, ^*P<0.05) are shown.

The effects of preincubation with CPEC on the effects of dFdC with respect to cell proliferation (A and B), loss of clonogenic capacity after correction for the cytotoxicity of CPEC alone ((C) Panc-1: 0.71±0.12; Miapaca-2: 1.00±0.06; SWp: 1.07±0.08; SWg: 0.85±0.26) and induction of apoptosis (D) in human pancreatic carcinoma (Panc-1, Miapaca-2 and BxPC-3) and NSCLC cells (SWp and its dFdC-resistant variant SWg). Representative examples (A and D) or means with standard errors of at least three separate experiments (B and C, ^*P<0.05) are shown.