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. 2007 Jun 26;97(1):1–5. doi: 10.1038/sj.bjc.6603844

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Copyright © 2007 Cancer Research UK

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A hypothetical effect of HDAC inhibitors on cellular epigenetic patterns in cancer. In addition to their promoter-specific effects, inhibitors of histone deacetylases (HDACis) may also increase the prevalence of cells with high acetylation levels of specific histone residues. This would shift the cellular epigenetic patterns from a poor (left) to better (right) prognosis. Histone demethylase inhibitors may have a similar effect on cellular methylation patterns.