Table 4. Multivariate Cox model for the association between survival and chemotherapy-induced neutropeniaa.
| Adjusted hazard ratio (95% CI) | P | |
|---|---|---|
| Neutropenia | ||
| 1 vs 0 | 0.72 (0.54–0.95) | 0.0189 |
| 2 vs 0 | 0.63 (0.50–0.78) | <0.0001 |
| 3–4 vs 0 | 0.71 (0.51–0.98) | 0.0388 |
| Age | ||
| ⩾60 vs <60 | 0.97 (0.84–1.13) | 0.7012 |
| Gender | ||
| Male vs female | 1.12 (0.94–1.34) | 0.2167 |
| BSA (m2) | ||
| ⩾1.50 vs <1.50 | 0.87 (0.74–1.02) | 0.0878 |
| ECOG PS | ||
| 1 vs 0 | 1.48 (1.28–1.71) | <0.0001 |
| Disease status | ||
| Advanced vs recurrent | 1.20 (1.03–1.40) | 0.0199 |
| Liver metastasis | ||
| Present vs absent | 1.73 (1.47–2.03) | <0.0001 |
| Leucocytes ( × 109 l −1 ) | ||
| 9.0–12.0 vs 4.0–9.0 | 1.46 (1.19–1.80) | 0.0004 |
Abbreviations: BSA, body surface area; ECOG PS, Eastern Cooperative Oncology Group performance.
a
Neutropenia is treated as a time-dependent variable.