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. 2007 May 22;97(1):133–139. doi: 10.1038/sj.bjc.6603822

Table 1. Numbers and proportions of women hrHPV+ve and adjusted multivariate ORs for socio-demographic and lifestyle factors.

  Total (n) hr HPV+ve (n) % hrHPV+ve Multivariate ORa 95% CI
Overall 5038 1973 39.2    
           
Tertiary education/training
 No degree 4122 1656 40.2 1 Reference
 Degree 887 305 34.4 0.72 0.61–0.87
 Missing 29 12 41.4    
        Global χ12=12.85, P=0.0003
           
Ethnicity
 White 4787 1868 39.0 1 Reference
 Other (non-white) 223 95 42.6 1.42 1.03–1.94
 Missing 28 10 35.7    
        Global χ12=4.68, P=0.0306
           
Marital status
 Married/living as married 2824 840 29.8 1 Reference
 Divorced/separated/widowed 667 289 43.3 1.97 1.62–2.40
 Single 1494 826 55.3 1.29 1.09–1.53
 Missing 53 18 34.0    
        Global χ22=47.80, P<0.0001
           
Ever pregnantb
 No 1589 855 53.8 1 Reference
 Yes 3412 1104 32.4 0.75 0.63–0.89
 Missing 37 14 37.8    
        Global χ12=11.30, P=0.0008
           
Age at first pregnancyb
 Never pregnant 1589 855 53.8 1 Reference
 First pregnancy aged <20 years 1080 453 41.9 0.86 0.71–1.05
 First pregnancy aged over 20 years 2303 640 27.8 0.67 0.55–0.80
 Missing 66 25 37.9    
        Global χ22=19.76, P=0.0001
           
Childrenb
 No 2113 1096 51.9 1 Reference
 Yes 2869 854 29.8 0.71 0.60–0.83
 Missing 56 23 41.1    
        Global χ12=17.06, P<0.0001
           
Number of childrenb,c
 1 793 324 40.9 1 Reference
 2 1170 288 24.6 0.75 0.59–0.95
 3 563 148 26.3 0.89 0.67–1.19
 4 190 49 25.8 0.82 0.54–1.24
 5–8 86 25 29.1 1.11 0.64–1.94
 Missing 67 20 29.9    
        Global χ42=7.23, P=0.1242
           
Caesarean everb,c
 No 2367 704 29.7 1 Reference
 Yes 481 145 30.2 1.12 0.88–1.43
 Missing 21 5 23.8    
        Global χ12=0.85, P=0.3574
           
Reproductive historyd
 Never pregnant 1589 855 53.8 1 Reference
 First pregnancy <age 20 years, have children 867 335 38.6 0.79 0.64–0.99
 First pregnancy <age 20 years, no children 205 113 55.1 1.01 0.73–1.40
 First pregnancy ⩾age 20 years, have children 1981 513 25.9 0.61 0.50–0.75
 First pregnancy ⩾age 20 years, no children 313 125 39.9 0.83 0.62–1.10
 Missing 83 32 38.6    
        Global χ42=25.55, P<0.0001
           
Current barrier contraception
 No 4211 1611 38.3 1 Reference
 Yes 811 354 43.7 1.05 0.87–1.27
 Missing 16 8 50.0    
        Global χ12=0.29, P=0.5907
           
Hormonal contraceptione
 Never pill user/no other current hormonal contraception 2416 649 26.9 1 Reference
 Never pill user/currently use other hormonal contraception 200 101 50.5 1.58 1.13–2.21
 Ex-pill user/no other current hormonal contraception 551 256 46.5 1.33 1.06–1.66
 Ex-pill user/currently use other hormonal contraception 98 48 49.0 1.12 0.71–1.76
 Current pill 1694 889 52.5 1.54 1.30–1.84
 Missing 79 30 38.0    
        Global χ42=27.33, P<0.0001
           
Physical activityf
 Never 720 275 38.2 1 Reference
 Ever 4239 1665 39.3 0.86 0.71–1.04
 Missing 79 33 41.8    
        Global χ12=2.40, P=0.1216
           
Smoking status
 Never smoker 2340 862 36.8 1 Reference
 Ex-smoker 851 264 31.0 0.88 0.73–1.07
 Current smoker 1798 822 45.7 1.21 1.04–1.40
 Missing 49 25 51.0    
        Global χ22=11.83, P=0.0027
           

Abbreviations: CI, confidence interval; hrHPV+ve, hrHPV positive; OR, odds ratio.

a

Multivariate OR adjusted for age/smear, tertiary education/training, ethnicity, marital status, reproductive history, use of hormonal contraception and smoking status.

b

Multivariate OR adjusted for age/smear, tertiary education/training, ethnicity, marital status, use of hormonal contraception and smoking status.

c

Restricted to women who have had children.

d

Ever been pregnant, age at first pregnancy and ever had children were all individually associated with hrHPV. As these variables are related, a composite variable was created and fitted in model.

e

Women were classified into one of five categories on the basis of current use of oral contraceptive pill or other hormonal contraception, and on any previous oral contraceptive pill use.

f

There was no effect on risk of hrHPV of physical activity (never/ever) or of frequency of physical activity (data not shown).