Table 1. Numbers and proportions of women hrHPV+ve and adjusted multivariate ORs for socio-demographic and lifestyle factors.
Total (n) | hr HPV+ve (n) | % hrHPV+ve | Multivariate ORa | 95% CI | |
---|---|---|---|---|---|
Overall | 5038 | 1973 | 39.2 | ||
Tertiary education/training | |||||
No degree | 4122 | 1656 | 40.2 | 1 | Reference |
Degree | 887 | 305 | 34.4 | 0.72 | 0.61–0.87 |
Missing | 29 | 12 | 41.4 | ||
Global χ12=12.85, P=0.0003 | |||||
Ethnicity | |||||
White | 4787 | 1868 | 39.0 | 1 | Reference |
Other (non-white) | 223 | 95 | 42.6 | 1.42 | 1.03–1.94 |
Missing | 28 | 10 | 35.7 | ||
Global χ12=4.68, P=0.0306 | |||||
Marital status | |||||
Married/living as married | 2824 | 840 | 29.8 | 1 | Reference |
Divorced/separated/widowed | 667 | 289 | 43.3 | 1.97 | 1.62–2.40 |
Single | 1494 | 826 | 55.3 | 1.29 | 1.09–1.53 |
Missing | 53 | 18 | 34.0 | ||
Global χ22=47.80, P<0.0001 | |||||
Ever pregnantb | |||||
No | 1589 | 855 | 53.8 | 1 | Reference |
Yes | 3412 | 1104 | 32.4 | 0.75 | 0.63–0.89 |
Missing | 37 | 14 | 37.8 | ||
Global χ12=11.30, P=0.0008 | |||||
Age at first pregnancyb | |||||
Never pregnant | 1589 | 855 | 53.8 | 1 | Reference |
First pregnancy aged <20 years | 1080 | 453 | 41.9 | 0.86 | 0.71–1.05 |
First pregnancy aged over 20 years | 2303 | 640 | 27.8 | 0.67 | 0.55–0.80 |
Missing | 66 | 25 | 37.9 | ||
Global χ22=19.76, P=0.0001 | |||||
Childrenb | |||||
No | 2113 | 1096 | 51.9 | 1 | Reference |
Yes | 2869 | 854 | 29.8 | 0.71 | 0.60–0.83 |
Missing | 56 | 23 | 41.1 | ||
Global χ12=17.06, P<0.0001 | |||||
Number of childrenb,c | |||||
1 | 793 | 324 | 40.9 | 1 | Reference |
2 | 1170 | 288 | 24.6 | 0.75 | 0.59–0.95 |
3 | 563 | 148 | 26.3 | 0.89 | 0.67–1.19 |
4 | 190 | 49 | 25.8 | 0.82 | 0.54–1.24 |
5–8 | 86 | 25 | 29.1 | 1.11 | 0.64–1.94 |
Missing | 67 | 20 | 29.9 | ||
Global χ42=7.23, P=0.1242 | |||||
Caesarean everb,c | |||||
No | 2367 | 704 | 29.7 | 1 | Reference |
Yes | 481 | 145 | 30.2 | 1.12 | 0.88–1.43 |
Missing | 21 | 5 | 23.8 | ||
Global χ12=0.85, P=0.3574 | |||||
Reproductive historyd | |||||
Never pregnant | 1589 | 855 | 53.8 | 1 | Reference |
First pregnancy <age 20 years, have children | 867 | 335 | 38.6 | 0.79 | 0.64–0.99 |
First pregnancy <age 20 years, no children | 205 | 113 | 55.1 | 1.01 | 0.73–1.40 |
First pregnancy ⩾age 20 years, have children | 1981 | 513 | 25.9 | 0.61 | 0.50–0.75 |
First pregnancy ⩾age 20 years, no children | 313 | 125 | 39.9 | 0.83 | 0.62–1.10 |
Missing | 83 | 32 | 38.6 | ||
Global χ42=25.55, P<0.0001 | |||||
Current barrier contraception | |||||
No | 4211 | 1611 | 38.3 | 1 | Reference |
Yes | 811 | 354 | 43.7 | 1.05 | 0.87–1.27 |
Missing | 16 | 8 | 50.0 | ||
Global χ12=0.29, P=0.5907 | |||||
Hormonal contraceptione | |||||
Never pill user/no other current hormonal contraception | 2416 | 649 | 26.9 | 1 | Reference |
Never pill user/currently use other hormonal contraception | 200 | 101 | 50.5 | 1.58 | 1.13–2.21 |
Ex-pill user/no other current hormonal contraception | 551 | 256 | 46.5 | 1.33 | 1.06–1.66 |
Ex-pill user/currently use other hormonal contraception | 98 | 48 | 49.0 | 1.12 | 0.71–1.76 |
Current pill | 1694 | 889 | 52.5 | 1.54 | 1.30–1.84 |
Missing | 79 | 30 | 38.0 | ||
Global χ42=27.33, P<0.0001 | |||||
Physical activityf | |||||
Never | 720 | 275 | 38.2 | 1 | Reference |
Ever | 4239 | 1665 | 39.3 | 0.86 | 0.71–1.04 |
Missing | 79 | 33 | 41.8 | ||
Global χ12=2.40, P=0.1216 | |||||
Smoking status | |||||
Never smoker | 2340 | 862 | 36.8 | 1 | Reference |
Ex-smoker | 851 | 264 | 31.0 | 0.88 | 0.73–1.07 |
Current smoker | 1798 | 822 | 45.7 | 1.21 | 1.04–1.40 |
Missing | 49 | 25 | 51.0 | ||
Global χ22=11.83, P=0.0027 | |||||
Abbreviations: CI, confidence interval; hrHPV+ve, hrHPV positive; OR, odds ratio.
Multivariate OR adjusted for age/smear, tertiary education/training, ethnicity, marital status, reproductive history, use of hormonal contraception and smoking status.
Multivariate OR adjusted for age/smear, tertiary education/training, ethnicity, marital status, use of hormonal contraception and smoking status.
Restricted to women who have had children.
Ever been pregnant, age at first pregnancy and ever had children were all individually associated with hrHPV. As these variables are related, a composite variable was created and fitted in model.
Women were classified into one of five categories on the basis of current use of oral contraceptive pill or other hormonal contraception, and on any previous oral contraceptive pill use.
There was no effect on risk of hrHPV of physical activity (never/ever) or of frequency of physical activity (data not shown).