Table A1.

Event	Abbreviation	Time assigned to
Any reversible subjective toxic effecta of grade 3 or higher during chemotherapy	TOX	Applied to the entire month
Alopecia and weight gain during chemotherapy	TOX	Include an additional 3 months after last report to allow for recovery
Any subjective toxic effecta of grade 3 or higher following chemotherapy	TOX	Include the total duration of toxic effect until resolution
Any relapse (including ipsilateral breast relapse) or the appearance of a second primary cancer	REL	Applies to entire remaining survival period
None of the above	TWiST	Applies to any remaining survival time

^aSubjective toxic effects include those noted and graded by the investigators: nausea, vomiting, diarrhoea, stomatitis, mucositis, haemorrhage, vaginal bleeding, infections, anorexia, epigastric pain, pulmonary, neurotoxicity, depression, skin allergy, alopecia, cystitis, headache, muscle weakness, hypercalcaemia, hypertension, hot flashes, euphoria, depression, thrombosis, phlebitis, embolism, oedema, lymphedema, weight gain, eye disorders, joint pain, wound healing, bone pain, fever, cardiac rhythm, cardiac function, pericarditis, cardiac failure, colitis, hypothyrosis, dental damage, post-RT pneumonitis, peripheral neuropathy, fatigue.