Table 1. Enzymes that modulate p53 stability.
| E3 ligases | E2 ligases | DUBs | Others |
|---|---|---|---|
| Mdm2 | Ubc9 | HAUSP | YY1 |
| Cop1 | Ubc13 | (USP7) | LZAP |
| PIRH2 | UbcH5B/C | USP2a | Prolyl isomerase Pin1 |
| ARF-BP1 | Ribosomal proteins | ||
| WWP1 | L11, L23 | ||
| E6/E6-AP | |||
| TOPORS | |||
| CUL4 | |||
| p53RFP | |||
| STUB1 (CHIP) |
ARF-BP1=alternative reading frame-binding protein 1; CHIP=carboxy terminus of Hsp70-interacting protein; COP1=constitutively photomorphogenic 1; CUL4=cullin 4; HAUSP=herpesvirus-associated ubiquitin-specific protease; LZAP=leucine-zipper-containing ARF-binding protein; Mdm2=mouse double minute 2; PIRH2=p53-induced RING-H2 protein; p53RFP=p53-inducible RING-finger protein; STUB1=STIP1 homology and U-box containing protein 1; TOPORS=topoisomerase I-binding RS protein; Ubc=ubiquitin-conjugating enzyme; USP=ubiquitin-specific protease; YY1=Yin Yang 1.