Table 5. Association between EGFR FISH results in the cytological specimens and matched biopsy specimens from all NSCLCs (n=33) and from the subgroup of primary NSCLCs without specimens from regional lymph node metastases (n=26).
| Cytological specimens (%) | Biopsy specimens (%) | P-value | |
|---|---|---|---|
| Total | 33 | 33 | |
| FISH positive | 21 (63.6) | 8 (24.2) | |
| High polysomy | 19 (57.6) | 5 (15.1) | |
| Amplification | 2 (6) | 3 (9.1) | |
| FISH negative | 12 (36.4) | 25 (75.8) | |
| <0.01a | |||
| Primary tumour b | 26 | 26 | |
| FISH positive | 16 (61.5) | 7 (26.9) | |
| High polysomy | 14 (53.8) | 4 (15.4) | |
| Amplification | 2 (7.7) | 3 (11.5) | |
| FISH negative | 10 (38.5) | 19 (73.1) | |
| 0.01a |
EGFR=epidermal growth factor recepetor gene; FISH=fluorescence in situ hybridisation; NSCLC=non-small-cell lung carcinoma.
a
P-value for difference in FISH positivity between cytology and biopsy.
b
Both cytology and biopsy from the primary tumour site.