Table 3.
Vision function in HIV individuals without retinitis: significant* associations between demographic, health, virologic, and immunologic measures with abnormal pattern standard deviation†
| No. eyes | Odds ratio of Abnormal PSD (95% CI) | P | |
|---|---|---|---|
| Age (yrs) | 0.03 | ||
| < 35 | 299 | 1.0 (reference) | |
| 35 – 42 | 654 | 1.0 (0.7 – 1.4) | |
| 43 – 49 | 575 | 1.1 (0.8 – 1.6) | |
| 50+ | 302 | 1.6 (1.1 – 2.5) | |
| Insurance type | 0.01 | ||
| Uninsured | 298 | 1.4 (1.0 – 2.1) | |
| Medicaid | 216 | 1.2 (0.8 – 1.8) | |
| Medicare | 639 | 1.6 (1.2 – 2.1) | |
| Private/VA/Champus | 677 | 1.0 (reference) | |
| Hgb (g/dL) | 0.03 | ||
| < 12.5 | 433 | 1.7 (1.2 – 2.4) | |
| 12.5 – 13.9 | 535 | 1.3 (0.9 – 1.8) | |
| 14.0 – 14.9 | 423 | 1.3 (0.9 – 1.8) | |
| 15.0+ | 439 | 1.0 (reference) | |
| Karnofsky score | 0.02 | ||
| < 80 | 271 | 1.6 (1.0 – 2.5) | |
| 80 | 550 | 1.5 (1.0 – 2.2) | |
| 90 | 713 | 1.0 (0.7 – 1.5) | |
| 100 | 296 | 1.0 (reference) |
PSD = pattern standard deviation.
*
Based on backward stepwise logistic regression of 18 covariates (cohort, sex, race, age, education, insurance status, hemoglobin level, Karnofsky score, HIV risk factor, time since AIDS diagnosis, no. of OIs, HAART status, HIV viral load, CD4 count, nadir CD4 count, CD8 count, CMV viral load, and right vs. left eye) with probability of removal p>0.05.
†
Defined as greater than 97.5 percentile derived from 123 similarly aged subjects with normal vision. Event rate is 33.4% (612/1830).