Figure 2.

Activation of the human and murine lymphotactin receptor by human, murine and viral agonists. Dose-response experiments measuring IP₃ turnover in COS-7 cells transiently transfected with the human and murine lymphotactin receptors XCR1 and mXCR1 and the promiscuous chimeric G-protein Gqi4myr using increasing concentrations of the agonists XCL1 (black square), mXCL1 (black triangle) and vCCL3 (white circle). The thin line indicate the EC₅₀ for the particular ligand (assuming Emax equal to that of vCCL3). All assays were performed in duplicate.