Table 1.

Plasma lipids in wild-type and apolipoprotein E knockout mice fed low and high fat diets

Diet	Gene	Cholesterol (mM) mean ± S.E.M	Triglyceride (mM) mean ± S.E.M
LF	WT	2.1 ± 0.05	0.69 ± 0.19
LF	Apo E KO	*6.95 ± 1.97	0.68 ± 0.09
HF	WT	2.2 ± 0.46	0.42 ± 0.12
HF	Apo E KO	*14.3 ± 0.01	0.38 ± 0.12

*P < 0.05

S.E.M = standard error of the mean

Table shows plasma cholesterol and triglyceride concentrations (mean ± SEM, n = 6 mice per group) in C57BL/6J WT mice and apo E KO mice maintained on either LF or HF diet for six-months. Apo E KO mice had significantly elevated levels of plasma cholesterol compared to WT controls under both feeding regimens (P < 0.05). High-fat feeding further exacerbated the elevation of cholesterol in apo E KO mice compared to HF-WT (P < 0.001) and LF-APOE KO mice (P < 0.05). Plasma triglyceride was not significantly different between groups.